Place it at the exact frame of the reveal in your edit, before any commentary follows. Follow it with Emotional Damage when the moment turns into a setback, or close the sequence with Bruh for a flat contrast after the big reaction.
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The clip is a voice exclamation of Damn Son lasting just under two seconds, delivered with drawn out emphasis. It gives a funny feeling of impressed disbelief, a stunned, over the top approval that makes an ordinary reaction sound much bigger than it really is.