D'oh was popularised by Homer Simpson in The Simpsons, which premiered in 1989, with Dan Castellaneta voicing the line as a quick annoyed grunt inspired by older comedy catchphrases. The expression became so embedded in popular culture that it entered dictionaries in 2001. Online, creators remixed the clip into exaggerated loud versions for meme edits, where it sits alongside other reaction staples like bruh in soundboard collections. Its staying power comes from instant recognition, a single syllable can signal a dumb mistake without any setup or explanation needed.