Professor E. Gadd first appeared in Nintendo's Luigi's Mansion, released for the GameCube in 2001, as the eccentric scientist who gives Luigi the Poltergust vacuum and runs the laboratory between haunted missions. The lab music became a shorthand for his workshop in fan edits and gameplay videos, and short clips of it later spread through meme soundboards where users searched for the lab theme on its own. It remains popular because it instantly signals invention, experimentation and Luigi's ghost-hunting world without needing any spoken lines.