Place it right after a Vine Boom or MLG Air Horn moment in your edit to end that bit cleanly, then follow with a fresh punchline sound so the next gag starts from a clean slate.
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This clip is just over a second of empty audio with no voice, music or effect at all, made to cut off other sounds playing at the same time. Pressing it feels oddly satisfying and a little awkward, like hitting mute mid-chaos and getting a clean, quiet reset instead.