Place it at the very end of a scene that builds up an impossible request, letting it close the exchange before anything else speaks. Follow it with Nope Avi for a second refusal, or with Sad Trombone to close the scene on the failed request.
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This is a short, flat spoken refusal lasting under two seconds, delivered in German as 'Computer sagt nein' in a bored, bureaucratic tone. It feels deadpan and awkwardly funny, like being shut down without discussion or appeal. The line comes from Little Britain, where it became the show's best-known brush-off for impossible requests.