Place it at the peak of a mishap, after a Sudden Suspense cue builds the tension and before an Oh My God Wow reaction lands. For a game fail, follow a Wrong Answer Game Show sting with it, then let a Cartoon Slip finish the sequence.
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This clip is a single man letting out a long, loud AAAHHHHH scream that stretches for about ten seconds, with his voice rising and cracking as it goes on. It feels frantic, over-the-top and funny, like panic turned up too loud for the situation, and it works because the scream keeps going past the point you expect it to stop.