Place it as the payoff after a montage of repeated interruptions, then follow it with Oh My God Wow for the stunned reaction and No No Wait Wait when someone tries to argue back. Keep it as the single turning point in the scene, with quieter reactions around it.
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This short Spanish voice clip features Luisa Albinoni shouting that she is completely fed up, her voice rising with frustration and exasperation in under four seconds. It feels blunt, cathartic and funny, like letting out a complaint you have held in too long. The line is delivered by Albinoni herself, giving the outburst a theatrical, over-the-top edge.