Place it as the payoff after the setup clip, then follow it with a short reaction sound so the joke lands and the audience can breathe. A fart effect works before it as a smaller warning, while a deadpan reaction after it keeps the moment from overstaying its welcome.
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This roughly 12-second meme clip carries a crude Russian title about diarrhea breaking through, used as a blunt gag for shock laughs. It feels gross, awkward and deliberately over the top, the kind of joke that lands because it is too much, turning an embarrassing bodily moment into a punchline for friends who enjoy crude humour.