Put it at the climax of a reaction edit, right after the reveal, then follow it with a Yoooooooooooo sound for a second response, or cut straight to a Shocking Sound Effect Button for a sharp contrast before the next scene.
Über diesen Sound
This is a long human scream built around a single drawn-out 'aaaa', lasting about twelve seconds. It feels over-the-top and exasperated, like someone giving in to a frustration they cannot hold back any longer, and it lands as pure comic release.