American Venom takes its name from the final mission of Red Dead Redemption 2, Rockstar Games' acclaimed western released in 2018. The mission closes the game's long epilogue and brings its central rivalry to a head in a snowy mountain confrontation. Clips taken from that sequence began circulating on YouTube, TikTok and soundboards as shorthand for a long-awaited reckoning. Creators still reuse it because the title and mood are instantly recognisable to players, turning an ordinary edit into a moment that feels like the end of a story.