Red Dead Redemption 2 was released in 2018, and American Venom is the name of its final epilogue mission, where John Marston tracks down Micah Bell for a last confrontation in the snow. The music attached to that chapter became closely linked with Marston's return and the game's closing arc. Clips of the theme spread through gaming edits, montages and soundboards because the mission is widely remembered as a peak moment. Its short, building excerpt now works online as shorthand for revenge, closure and a western finale.