Place it at the end of a failed play, after the mistake is fully visible, then follow it with SpongeBob Fail for a second laugh or Vine Boom to underline the collapse. Keep it as the final reaction in the edit, and save a bigger sound for the next moment.
Über diesen Sound
This is a short voice clip from streamer CaseOh, lasting about 2.4 seconds, built around his deadpan line about losing the will to live. It lands as dark, defeated humour, the sound of someone completely drained by what just happened on screen. It works because the delivery is flat and exhausted rather than dramatic, making the despair feel instantly relatable.