Place it at the very end of a fail sequence, after the mistake is clear, so it closes the edit instead of interrupting the action. For a longer reaction, follow it with the Bruh Sound Effect, or open the sequence with the Game Show Buzzer Sound Effect before the fail lands.
Über diesen Sound
This is a brief voice clip of Heavy from Team Fortress 2 saying, 'I am dead, not big surprise,' in a thick accent and a flat, underreactive delivery. It feels dryly funny and deliberately unbothered, turning an obvious defeat into a calm shrug rather than a dramatic reaction. The line comes from the game and became a widely used gaming meme for ironic exits and expected failures.