Place it at the end of a build-up where the reaction finally breaks, right before the payoff clip. Follow it with the laughing dog meme for a release, or lead into it with no no wait wait when the moment escalates too far.
Über diesen Sound
A 4.8-second voice clip of someone blurting out 'I can not hold it in anymore' as if they have reached their limit. It lands as desperate and funny at the same time, the sound of holding back laughter, tears or a confession for too long and finally letting it spill out.