Place it right after the lie is revealed in a skit, so the reaction becomes the punchline, then follow it with Sad Violin to stretch the reaction before cutting to the next scene.
Über diesen Sound
This is a short Portuguese spoken line lasting about six seconds, delivered in a hurt, dramatic voice that turns a small lie into a personal wound. It feels wounded and theatrical rather than angry, with the emphasis landing on the pain of being misled. The delivery makes it work as an exaggerated reaction to a fib, a tease or a playful betrayal among friends.