Put this clip in the middle of a reaction chain, after the Huh moment and before Oh My God Wow, so the call-out answers the confusion and sets up the amazement. It also works just before a cut back to normal gameplay footage.
Über diesen Sound
This is a short voice clip, about a second and a half long, of a man stretching out the words 'One Eye' in a loud, drawn-out shout. It lands as silly and over-the-top, turning a simple call-out into a goofy reaction. The clip comes from That Nate Guy on YouTube.