Place it at the end of a bad-advice skit, after the setup line lands, then follow it with Emotional Damage for the reaction and Bruh when the advice-giver doubles down.
Über diesen Sound
This 18-second clip is a Portuguese voice line built around the phrase 'stop having depression,' spoken as a flat dismissal of unhelpful advice. It gives listeners an awkward, darkly funny jolt, because the advice sounds simple while the feeling it dismisses is not.