Place it as the final beat in a late-night edit, after the last joke, and follow it with The End meme to close the sequence. If the scene needs one more beat, put an awkward moment sound just before it, so the ending stays in the right order.
Über diesen Sound
This is a short spoken clip lasting about 2.8 seconds, built around the two-syllable sound in its title and the Italian bedtime line its uploader wrote with it. It gives a sleepy, resigned feeling, like someone giving up on staying awake and admitting the night is done. It works as a light, end-of-the-day joke rather than a loud reaction.