Place it at the end of a build-up, after the choice is shown, then follow it with Hell Naw Dog for a second reaction beat, or open with Oh No No No before the plea for a two-part reaction sequence.
Über diesen Sound
This six-second clip is a single drawn-out, pleading voice calling out 'pookie nooo' in a high, desperate tone that stretches the last word into a wail. It feels funny, dramatic and a little heartbroken at once, like watching a friend make a terrible choice in slow motion and being powerless to stop them. The exaggerated distress makes the plea land as a joke rather than a real cry for help.