Place it at the exact frame the bad news lands, then follow it with the damn meme sound for the stunned reaction shot. If the scene needs a build-up, put the oh my god wow sound just before it so this clip becomes the final response.
Über diesen Sound
A very short voice clip of someone stretching out 'porque' in a drawn-out, whiny wail that lands like a spoken 'nooo'. At just over a second it is pure disbelief and disappointment, the sound of asking why something had to happen and already knowing there is no good answer.