Place it right after the awkward reveal, then follow it with Eww Brother Eww for a second reaction, or let Wrong Answer Game Show close the bit when the moment was a bad choice. Keep it as the centre of the reaction, with the other sounds supporting it from either side.
Über diesen Sound
The clip is a single drawn-out human groan, stretched across about nine seconds, with a low, wavering voice that sounds tired, fed up and thoroughly unimpressed. It feels awkward and funny at once, like a sigh that keeps going because the moment deserves it. Listeners hear pure exasperation, the kind that lands best when words would only make it worse.