Put it at the very end of the annoying exchange, just before the cut to the next scene, so the interruption becomes the joke. Follow it with the Bruh Sound Effect for a deadpan reaction, or use the Emotional Damage Meme Sound when the shut-down needs a bigger comic fallout.
Über diesen Sound
This two-second clip is a Russian voice snapping a rude shut-up line at someone who has gone too far. The delivery is loud, clipped and impatient, so it lands as genuine frustration rather than a light joke, and listeners can feel the anger even without understanding the words. It circulates in Russian-language meme communities as a fast reaction sound for edits and short videos.