Place it at the peak of a fail, after the setup has already made the mistake clear, then follow it with Scream Meme for a second reaction or Emotional Damage when the joke is about the aftermath. Keep it as the climax, not the opening, so the surrounding edit builds toward it.
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This is a roughly four-and-a-half-second clip of a deep male voice letting out a long, dramatic scream of “Nooooo,” stretched out and full of theatrical despair. It feels over-the-top and funny rather than frightening, like a cartoon reaction to bad news, and it works because the delivery is so big and committed.