Place it right after the line that triggers the reaction, then follow it with the fart with reverb for a second hit, or swap in the long brain fart when you want a different take on the same gag in your sequence.
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This clip is a slowed down fart effect stretched to about five seconds, pitched lower and drawn out far longer than a normal toot. It feels stupidly funny and a little gross, like a thought collapsing in real time, which is exactly why it lands as a brain aneurysm joke.