The Pain Elemental first appeared in Doom II in 1994 as a floating, brown demon that attacks by spitting flaming Lost Souls at the player. Its damage and death noises became familiar to players from repeated encounters in tight arenas. Clips of those noises later moved to soundboards and meme edits alongside other game hurt sounds, where the long owwww works less as horror and more as a comic reaction. Doom's lasting popularity keeps the enemy recognisable even to viewers who have never played the original games.
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The Pain Elemental owwww is the pained screech of the floating demon from Doom, used as a funny ouch reaction for fails, hits and gaming moments.
This clip captures the Pain Elemental from Doom letting out a long, drawn-out owwww when it takes damage. The sound is a raspy, monstrous wail that stretches the vowel out until it sounds almost cartoonish for such a threatening enemy. It does not read as real agony, which is why it lands as comedy when dropped over a minor injury or an embarrassing mistake. The contrast between the demon's floating, skull-spitting design and that whiny cry makes the moment instantly readable as an exaggerated ouch reaction.