Put it at the very end of a reaction edit as the final word, after the argument has built up. Lead into it with the damn meme sound for a smaller reaction first, then let this clip close the scene with nothing placed after it.
Sobre este sonido
A short voice clip, just under two seconds, of someone shouting the Portuguese phrase "Vão todos se ferrar!" in an angry outburst. It lands as furious and fed up, the sound of someone who has completely had enough, which makes the exaggerated rage feel funny rather than genuinely threatening when you play it out of context.