Down with the Sickness was released by Disturbed in 2000 as a single from their debut album The Sickness, and its opening vocalisation quickly became one of the most recognisable moments in nu metal. The short scream was later clipped, remixed and shared across meme pages and short-form video, where its aggressive energy made it a shorthand for losing control or going all out. Two decades on, it survives because the sound is instantly recognisable even without the song around it.