The phrase is Japanese for who is Marisa, a reference to Marisa Kirisame, the ordinary magician and one of the main characters of the Touhou Project games created by ZUN. The clip circulates on Japanese soundboards tagged with Hikakin, the Japanese YouTuber whose reaction videos and meme edits helped spread short voice cuts like this beyond their original context. Because the line is so brief and recognisable to Touhou fans, it has survived as a reusable in-joke, posted whenever Marisa is mentioned out of context or a newcomer asks who she is.
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Short Japanese voice clip asking who Marisa is, from the Hikakin Touhou meme. Creators use it as a confused reaction when a character appears unannounced.
This is a very short Japanese voice line that asks, in casual speech, who Marisa is. The delivery is quick and slightly puzzled, as if the speaker has just heard an unfamiliar name and wants an answer right away. At under a second, it works less like dialogue and more like a punctuation mark, cutting into a scene at the exact moment of confusion. Viewers familiar with Touhou will catch the reference to Marisa Kirisame immediately, while others still read the tone clearly as a blank, who-is-that reaction that needs no translation to land.