Nani is the Japanese word for what, shouted across countless anime series in moments of shock. It became a standalone meme in the late 2010s alongside the Omae wa mou shindeiru clip from Fist of the North Star, where the stunned reply turned into a template for edits. Clips spread through YouTube, Discord and soundboards as a universal reaction sound. It remains popular because it needs no translation, works over any language or footage, and instantly signals disbelief in a way a plain English what cannot match.