The line comes from Resident Evil 3: Nemesis, released in 1999, and returned in the 2020 remake, where Jill Valentine narrates the fall of Raccoon City during the T-virus outbreak. September 28 is the day her escape attempt begins, just before Nemesis starts hunting S.T.A.R.S. members. The quote became one of the series most quoted openings, shared in horror edits, memes and anniversary posts every September, because the calm delivery captures the whole franchise mood of one survivor against a ruined city.