Once in a Lifetime is a Talking Heads song from the band's 1980 album Remain in Light, written around a narrator questioning his house, car, and life choices. The highway line is part of that restless, self-interrogating sequence, which is why it works so well outside the song as a standalone reaction. Online, short clips of the lyric circulate as a meme sound for travel confusion, existential jokes, and edits where someone realises they have no idea where they are going. Its longevity comes from that simple, relatable question and Byrne's unmistakable delivery.