The line comes from Rockstar's 2004 action game Grand Theft Auto: San Andreas, voiced by Clifton Powell as Melvin 'Big Smoke' Harris. Early in the story Smoke attacks Carl Johnson with a baseball bat after mistaking his old friend for a burglar, then delivers the shout as he realises who it is. Clips of the scene spread through YouTube, forums and soundboards in the meme era, and the short isolated shout became a reusable reaction for trespassing, mistaken identity and walking into trouble.