Place it directly after the offending claim in your timeline, then cut straight to the reaction shot. Follow it with the damn meme sound for a second verdict, or precede it with a record scratch freeze-frame if the lie needs a clear build before the interruption lands.
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This is a short voice clip, just under two seconds, of someone shouting bullshit before stretching out a long, exasperated sheiittt. It lands as pure disbelief, the sound of someone who has heard enough and is not buying a word of it, which makes the outburst feel funny rather than genuinely angry.