Place it at the very end of a reaction sequence, after a bruh soundboard button for the letdown and an emotional damage sound button for the escalation, so Quadrizarrézimo closes the edit as the final escalation before you cut away.
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Quadrizarrézimo is a short meme clip built around a single shouted exclamation, delivered with stretched emphasis on the title word itself. The effect is deliberately excessive, turning a simple reaction into a loud, silly peak that feels funny and surprising rather than serious, which is why listeners reach for it when a normal reaction no longer feels like enough.