American Venom is the name of the final mission in Rockstar Games' Red Dead Redemption 2, released in 2018, where John Marston tracks down Micah Bell in the snowy mountains. Its opening music became a shorthand online for a point of no return, shared in edits far beyond the game itself. Players who finished the long epilogue associate the swell with payback and closure, which is why creators reuse it on TikTok and YouTube whenever a story, rivalry, or joke needs a serious, western style ending.