Put it at the end of a serious setup, then follow it with the shocked meme sound for the reaction and the oh no no no laugh to close the joke, keeping it as the only interruption in the middle of the edit.
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This is a single, very short fart sound lasting just over half a second, with a low, blunt burst that lands all at once. It feels rude, silly and instantly funny, the kind of noise that breaks a serious moment and makes people laugh before they can stop themselves.