Place it immediately after the question is shown on screen, as the response to that moment, then follow it with Oh My God Wow when you want a bigger reaction, or use Eww Brother Eww first when the joke is specifically about a brother.
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This is a short spoken reaction clip, lasting about one and a half seconds, in which a voice delivers the line about a brother asking a very good question with calm, approving emphasis. It feels amused and lightly sarcastic, the kind of dry praise that makes a clever question land harder in a group chat or a video. The delivery is brief and matter-of-fact, so the compliment becomes the punchline.