Place it at the end of a setup line, then follow it with Goofy Yell for a bigger reaction, or put Shocked Meme Sound just before it so it answers the shock.
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This clip is a 143-millisecond burst of nonsense vocal sound, built around the odd hou-ho-howouaff utterance in its title, with no words to follow and no message behind it. It lands as silly and surprising, the kind of abrupt noise that makes a listener laugh because it arrives out of nowhere and ends before they can place it.