Place it right after the question appears on screen in your edit, then follow it with the sad trombone, or let the sitcom laugh track close the scene after the pause that follows.
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This short spoken clip delivers the line 'It doesn't matter how you're doing' in a flat, dismissive voice, lasting just under three seconds. It feels blunt and unbothered, turning a polite question into a cold brush-off. That contrast makes it funny in the right moment, especially when someone expects sympathy and gets indifference instead.