The sound comes from the Loki season 1 finale in 2021, featuring Jonathan Majors as He Who Remains, a variant of Kang the Conqueror from Marvel comics. In the episode he presents Loki and Sylvie with a choice about the timeline and the multiverse, framing it with the line about what is the worst that can happen. Clips from the scene were later recorded and shared on soundboards as a standalone reaction, separated from the plot and reused whenever an enthusiastic yes fits a win, a dare, or a bad idea going ahead.