This clip comes from Family Guy, the long-running animated sitcom known for its cutaway gags and parodies of advertising mascots. In the scene, the Kool-Aid Man bursts through a wall in his familiar style, prompting the exasperated oh come on reaction that became the punchline. Shared widely on soundboards and in short-form videos, it stuck because the shout is instantly recognisable even without the visual, making it an easy shorthand for frustration, disbelief and comic timing.