Place it at the end of a setup line, just after the claim it answers, so the edit turns on a single beat. Follow it with the Bruh sound for a second reaction, or lead into it with the Emotional Damage sound when the joke is about failed expertise, then cut straight to the next scene.
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MDs is a 1.3-second meme clip, a single short burst made for quick reactions and repeat taps. It feels abrupt and playful, cutting into a quiet moment with just enough surprise to turn an ordinary exchange into a joke. Nothing lingers after it, so the humour comes from the timing rather than a long setup, and the next line can follow straight away.