Place it at the end of a rambling setup, then follow it with Damn Meme Sound as the next reaction in the exchange. Open with Oh My God Wow before the interruption to build the back-and-forth, and save Brother Eww Reaction Sound for the final reaction that closes the scene.
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This is a brief voice clip of one person snapping out the line “oh my god, shut up” in a fast, fed-up delivery that lasts about 2.7 seconds. It lands as playful frustration rather than real anger, the kind of exaggerated eye-roll you send when a joke drags on or someone keeps rambling. Its bluntness makes the irritation feel instantly recognisable and funny.