The phrase comes from everyday Mexican Spanish slang that spread online as a short reaction clip on soundboards and social media. Wey is an informal way to address a friend, and no mames is a vulgar but common expression of disbelief that is often softened in memes. Clips like this gained traction because the line works in many contexts, from agreeing sarcastically to calling out an obvious truth. It remains popular in WhatsApp chats, meme edits and short videos where a fast Spanish reaction fits better than an explanation.