Put it first in a reaction edit as the opening greeting to the person on screen, then follow it with the Let Me Know Sound Button for their reply, keeping this clip ahead of any wider group reaction that closes the sequence.
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This is a very short voice clip, under a second, of Jorge Luna saying the Spanish phrase “Qué fue mano” in a casual, upbeat tone. It gives a listener a funny, familiar feeling, like being greeted by a mate who is surprised and amused to see you. It comes from the Peruvian comedy show Hablando Huevadas.