The laugh comes from Ren and Stimpy, the Nickelodeon cartoon about a hyperactive chihuahua and a dim-witted cat, and is taken from the episode Stimpy's Invention. Ren, the short-tempered chihuahua, delivers the laugh at a moment of gleeful derangement, which made it easy to lift out of context. It later circulated on soundboards and in short meme edits, where creators reused it as a shorthand for someone losing their composure. Its exaggerated cartoon laugh keeps it useful for reaction videos long after the original episode aired.