Place it as the payoff after a calm setup, then follow it with Goofy Ahh Sounds for a second reaction before cutting to Emotional Damage when the joke turns on the speaker.
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This is a roughly ten-second meme clip centred on Caine, with a saturated treatment that pushes the sound into a loud, exaggerated burst. It feels chaotic, playful and affectionate, like a fan favourite turned up for maximum silliness, and it works best as a short jolt of cartoon energy.