Place it right after the request that pushes the character too far, as the reply that ends the exchange. Open with They Ask You How You Are to set up the question, let this line answer it, and close with Shocked Meme Sound for the other person's reaction.
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This is a short spoken line lasting just over four seconds, with one voice asking 'What more do you want from me?' in a strained, fed-up tone. It carries a burst of relatable frustration, sounding exhausted and defiant at once. That familiar feeling makes it funny, as if patience has finally run out after one request too many.