The phrase comes from everyday spoken German, where nisch is a colloquial, dialect version of nicht, giving nerv nisch a lazier, more fed up sound than the standard wording. Fresse is a crude word for mouth, so the whole line is much stronger than a polite request to be quiet. Short recordings of the saying circulate as reaction audio in German speaking chats and short video edits, where its brevity and rudeness make it reusable for almost any annoying interruption, tease or repeated request.