Place this clip at the end of a frustration build, after a failed attempt sequence. Lead in with a No No Wait Wait moment to show the warning, then let this line close it, and follow a beat later with a Damn reaction for the aftermath.
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The clip is a short 1.6-second voice line of someone flatly saying they are sick of this shit, delivered as a blunt fed-up outburst. It gives a listener that drained, exasperated feeling of hitting a limit, funny because the frustration is so direct and instantly relatable when patience runs out.